SUDOSCAN has been used to monitor patient outcomes
A key clinical application of SUDOSCAN is longitudinal follow-up and patient management. SUDOSCAN has good reproducibility and repeatability , which allows the physician to follow patient outcomes over time and assess the progression of neuropathy and the impact of lifestyle modification or medication.
In this section three cases provide meaningful examples of the utility of SUDOSCAN to monitor patients over time in different clinical applications.
Find the main publication list on using SUDOSCAN in the follow-up of patients click here.
1 – Vitamin B12 Supplementation in Diabetic Neuropathy monitored with SUDOSCAN 
The effect of normalizing vitamin B12 levels with 1 mg/day of oral B12 (methylcobalamin) for one year in type 2 diabetes patients with diabetic neuropathy has been investigated in a randomized, double-blind, placebo-controlled study by measuring sudomotor function using SUDOSCAN.
90 patients with type 2 diabetes well controlled using metformin for at least four years, and suffering from both peripheral and autonomic diabetic neuropathy were tested to evaluate neurophysiological parameters, sudomotor function (autonomic dysfunction) measured with SUDOSCAN, pain score, and quality of life. After 12 months of oral B12 supplementation, there were increased plasma B12 levels and significant improvements of all neurophysiological parameters, sudomotor function, pain score, and quality of life among patients randomized to receive B12 supplementation.
2 – SUDOSCAN in wild-type cardiac amyloidosis 
Patients with cardiac wild-type amyloidosis (ATTRwt-CA) and controls matched by age, gender, and body mass index were evaluated for autonomic neuropathy assessed by electrochemical skin conductance (ESC) measured using SUDOSCAN. The relationship between ESC scores, functional cardiac status, and prognosis were reported.
The results demonstrated that SUDOSCAN feet ESC measures were reduced in almost 50% of patients with ATTRwt-CA and were associated with a worse prognosis, helping identify patients at higher risk for a poor outcome.
3 – The effect of lifestyle intervention evaluated with SUDOSCAN 
SUDOSCAN was used to evaluate the effect of physical activity on cardiovascular risk and metabolic disease. Among 650 subjects involved in a 12-month training program, those with the highest level of weekly physical activity (as measured with a pedometer) showed an improvement in sudomotor function measured with SUDOSCAN which was the most significant change over 1 year.
No patient preparation
Results in 3 minutes
Easy-to-read critical data points to help physicians reach a diagnosis
Easy to operate
CE and FDA approvals
Reproducible quantitative results
Independent from environmental conditions
Backed by evidence-based research
150 peer-reviewed journals publications
 L. Bordier et al. Accuracy of a Rapid and Non-Invasive Method for the Assessment of Small Fiber Neuropathy Based on Measurement of Electrochemical Skin Conductances. Front Endocrinol (Lausanne). 2016 Feb 29;7:18. T. Didangelos et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2021, 13(2), 395. Kharoubi M, Roche F, Bézard M, Hupin D, Silva S, Oghina S, Chalard C, Zaroui A, Galat A, Guendouz S, Canoui-Poitrine F, Hittinger L, Teiger E, Lefaucheur JP, Damy T. Prevalence and prognostic value of autonomic neuropathy assessed by Sudoscan® in transthyretin wild-type cardiac amyloidosis. ESC Heart Fail. 2021 Apr;8(2):1656-1665. A. Raisanen et al. Sudomotor Function as a Tool for Cardiorespiratory Fitness Level Evaluation: Comparison with Maximal Exercise Capacity. Int J Environ Res Public Health. 2014 May 30;11(6):5839 48.