Peripheral neuropathy is the result of damage to peripheral nerves, including small fiber neuropathy involving small and myelinated nerves (Aδ), as well as unmyelinated nerves (unmyelinated C fibers). In peripheral neuropathy, small somatic and autonomic fibers can be affected. Small fibers control thermal perception, pain perception, and autonomic functions such as cardiac, pulmonary or enteric functions .
Peripheral neuropathy can be a complication of several diseases such as diabetes, neurological or metabolic disorders, and infections. It can also result from certain drugs or alcohol consumption.
This complication can occur in the very early stages of disease. Its detection may help physicians to better manage their patients and avoid advanced complications.