Screening diabetic neuropathy with SUDOSCAN in type 2 diabetes and prediabetes
Juan J. Cabré, Teresa Mur, Bernardo Costa, Francisco Barrio, Charo López-Moya, Ramon Sagarra, Montserrat García-Barco, Jesús Vizcaíno, Immaculada Bonaventura, Nicolau Ortiz, Gemma Flores-Mateo, Oriol Solà-Morales and the Catalan Diabetes Prevention Research Group.
Article title: Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement
for the Screening of Diabetic Neuropathy in Primary Care. Decoding Study (Dermal Electrochemical Conductance in Diabetic Neuropathy).
J. Clin. Med. 2019, 8(5), 598.
J. Cabré et al from Catalan Diabetes Prevention Research Group, Barcelona, Spain, analyzed the feasibility and effectiveness of dermal electrochemical conductance (DEC) measured with SUDOSCAN (quantitative expression of sudomotor reflex, generally called Electrochemical Skin Conductance, ESC) as a screening test of diabetic neuropathy (DPN) in primary health care centers.
Diabetic neuropathy (DNP) is the most common complication of diabetes and is of great clinical significance mainly due to the pain and the possibility of ulceration in the lower limbs. Early detection of neuropathy is essential in the medical management of this complication.
In patients with peripheral neuropathy, thin fibers (autonomic system—sweating) and thermal and tactile sensitivity are first affected, followed by the involvement of large fibers, presenting an altered vibrating sensation which eventually alters electromyography (EMG) patterns. Therefore, dysfunction of the sweat reflex in small distal fibers is one of the earliest changes detected in these patients.
This blind, prospective study included 197 people with type 2 diabetes (n=100), prediabetes (n=50) and normal tolerance (n=47), who underwent all the protocol tests and electromyography (EMG).
SUDOSCAN results (DEC, i.e., ESC) in the three groups are reported in the Table below: